How to Read Bonferroni Table for Significant Differences
Post Hoc Tests
Post hoc (Latin, meaning "afterwards this") means to clarify the results of your experimental data. They are oft based on a familywise mistake rate; the probability of at to the lowest degree one Type I error in a set (family) of comparisons.
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The well-nigh common post hoc tests are:
- Bonferroni Process
- Duncan's new multiple range exam (MRT)
- Dunn's Multiple Comparison Test
- Fisher'due south Least Significant Departure (LSD)
- Holm-Bonferroni Procedure
- Newman-Keuls
- Rodger's Method
- Scheffé's Method
- Tukey's Test (see likewise: Studentized Range Distribution)
- Dunnett's correction
- Benjamini-Hochberg (BH) procedure
Bonferroni Procedure (Bonferonni Correction)
This multiple-comparison mail hoc correction is used when you are performing many contained or dependent statistical tests at the aforementioned time. The trouble with running many simultaneous tests is that the probability of a pregnant result increases with each examination run. This mail hoc test sets the significance cut off at α/north. For example, if you lot are running xx simultaneous tests at α = 0.05, the correction would be 0.0025. More detail. The Bonferroni does endure from a loss of power. This is due to several reasons, including the fact that Type II error rates are high for each test. In other words, information technology overcorrects for Blazon I errors.
Holm-Bonferroni Method
The ordinary Bonferroni method is sometimes viewed as besides conservative. Holm'southward sequential Bonferroni post hoc test is a less strict correction for multiple comparisons. Run into: Holm-Bonferroni method for a step-by-pace example.
Duncan's new multiple range test (MRT)
When you lot run Assay of Variance (ANOVA), the results will tell you lot if there is a difference in means. However, it won't pinpoint the pairs of means that are different. Duncan'due south Multiple Range Test will identify the pairs of means (from at least three) that differ. The MRT is similar to the LSD, simply instead of a t-value, a Q Value is used.
Fisher'due south Least Significant Difference (LSD)
A tool to identify which pairs of means are statistically different. Essentially the same every bit Duncan'due south MRT, but with t-values instead of Q values. See: Fisher'southward Least Significant Departure.
Newman-Keuls
Like Tukey's, this post hoc test identifies sample means that are different from each other. Newman-Keuls uses different critical values for comparing pairs of means. Therefore, it is more than probable to find significant differences.
Rodger'south Method
Considered by some to be the virtually powerful post hoc examination for detecting differences amidst groups. This test protects against loss of statistical power as the degrees of liberty increment.
Scheffé's Method
Used when you lot want to look at post hoc comparisons in general (equally opposed to simply pairwise comparisons). Scheffe'south controls for the overall confidence level. Information technology is customarily used with unequal sample sizes.
See: The Scheffe Exam.
Tukey'south Test
The purpose of Tukey's test is to figure out which groups in your sample differ. It uses the "Honest Significant Departure," a number that represents the distance between groups, to compare every mean with every other mean.
Dunnett'due south correction
Similar Tukey's this post hoc exam is used to compare means. Different Tukey'southward, it compares every mean to a control hateful. For calculation steps, see: Dunnett's Examination.
Benjamini-Hochberg (BH) procedure
If you perform a very big amount of tests, one or more of the tests will accept a significant result purely by chance alone. This post hoc test accounts for that fake discovery rate. For more details, including how to run the procedure, see: Benjamini-Hochberg Process.
More than on the Bonferroni Correction
The Bonferroni correction (sometimes chosen the Bonferroni procedure) accounts for multiple tests.
The Bonferroni correction is used to limit the possibility of getting a statistically significant event when testing multiple hypotheses. It'southward needed because the more than tests you lot run, the more probable you are to become a significant result. The correction lowers the surface area where you can reject the null hypothesis. In other words, information technology makes your p-value smaller.
Imagine looking for the Ace of Clubs in a deck of cards: if you pull one card from the deck, the odds are pretty low (i/52) that you lot'll get the Ace of Clubs. Try again (and effort mayhap l times), you lot'll probably end up getting the Ace. The aforementioned principal works with hypothesis testing: the more simultaneous tests you run, the more likely you'll get a "significant" result. Let's say you were running 50 tests simultaneously with an blastoff level of 0.05. The probability of observing at least 1 pregnant event due to take chances lone is:
P (meaning result) = one – P(no significant event)
= 1 – (1-0.05)l = 0.92.
That'southward nigh certain (92%) that y'all'll get at to the lowest degree 1 significant outcome.
How to Summate the Bonferroni Correction
The calculation for this post-hoc test is actually very unproblematic, information technology'south just the blastoff level (α) divided by the number of tests you're running.
Sample question: A researcher is testing 25 different hypotheses at the same time, using a critical value of 0.05. What is the Bonferroni correction?
Answer:
Bonferroni correction is α/n = .05/25 = .002
For this set of 25 tests, yous would turn down the zero only if your p-value was smaller than .002.
The Bonferroni Correction and Medical Testing
Matthew A. Napierala, MD points out how multiple tests touch physicians (and patients) in an article for the American Academy of Orthopaedic Surgeons (AAOS). "In contemporary orthopaedic research studies, numerous simultaneous tests are routinely performed." This means that given enough tests, ane of them is spring to come back equally a false positive. Definitely non a good thing when we're talking almost health issues.
Post Hoc Test: References
AAOS. Research News. Retrieved January 1, 2020 from: http://world wide web.aaos.org/news/aaosnow/apr12/research7.asp
Levine, D. (2014). Even You Can Larn Statistics and Analytics: An Piece of cake to Empathise Guide to Statistics and Analytics 3rd Edition. Pearson FT Press
Melt, T. (2005). Introduction to Statistical Methods for Clinical Trials (Chapman & Hall/CRC Texts in Statistical Science) 1st Edition. Chapman and Hall/CRC
Wheelan, C. (2014). Naked Statistics. W. W. Norton & Company
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